Delete whole line in Irssi (^u).
http://wiki.fishcracker.net/wiki/Irssi
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Simple text editing on the input line
Key:
^ = control
meta = alt (usually)
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Delete the line: ^u
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Delete the word before the cursor: meta+backspace
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Paste the last deleted thing: ^y
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Go to the start of the line: ^a
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Go to the end of the line: ^e
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Go backwards by word: meta+b
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Go forwards by word: meta+f